ASIA unversity:Item 310904400/8504
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    题名: Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse
    作者: Chen, HY;Chen, Huey-Yi;Chung, YW;Chung, Ya-Wen;Lin, WY;Lin, Wei-Yong;Wang, JC;Wang, Jiunn-Chin;Tsai, FJ;Tsai, Fuu-Jen;Tsai, CH;Tsai, Chang-Hai
    贡献者: Department of Healthcare Administration
    关键词: Genotype;Collagen type 3 alpha 1 polymorphism;Pelvic organ prolapses;URINARY-INCONTINENCE;CESAREAN-SECTION;FLOOR DISORDERS;LIGAMENTS;RECEPTORS;WOMEN
    日期: 2008-10
    上传时间: 2010-03-26 10:52:50 (UTC+8)
    出版者: Asia University
    摘要: Objective: To investigate whether pelvic organ prolapse (POP) is associated with collogen 3 alpha 1 (COL3A1) polymorphisms and other factors. Methods: A case-control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1 rs1800255 and COL3A1 rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis. Results: The distribution of the COL3A1 rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1 rs1800255 genotype AA were significantly associated with risk of POP. Conclusion: There may be an association between COL3A1 genotype and risk of POP. (c) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
    關聯: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 103(1):55-58.
    显示于类别:[健康產業管理學系] 期刊論文

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