English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90096/105238 (86%)
Visitors : 7183499      Online Users : 435
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8527


    Title: A Novel Genetic Variant of BMP2K Contributes to High Myopia
    Authors: Liu, HP (Liu, Hsin-Ping);Lin, YJ (Lin, Ying-Ju);Lin, WY (Lin, Wei-Yong);Wan, L (Wan, Lei);Sheu, JJC (Sheu, Jim Jinn-Chyuan);Lin, HJ (Lin, Hui-Ju);Tsai, YH (Tsai, Yuhsin);Tsai, CH (Tsai, Chang-Hai);Tsai, FJ (Tsai, Fuu-Jen)
    Contributors: Department of Bioinformatics
    Keywords: high myopia;bone morphogenetic protein;single nucleotide polymorphism
    Date: 2009
    Issue Date: 2010-03-26 10:56:38 (UTC+8)
    Publisher: Asia University
    Abstract: Loss of eye growth regulation may cause myopia, because modulation of optic globe size is essential for the generation of normal optic power. Evidence has implied variations of BMP2 gene expression mediate ocular development and retinal tissue remodeling. Given BMP2 as a potential regulator involved in myopia development, we investigate whether gene BMP2-inducible kinase (BMP2K, BIKe), whose expression is up-regulated during BMP2-induced osteoblast differentiation, contributes to susceptibility of high myopia. Participants grouped into high myopia had a spherical equivalent greater than -6.00 D, compared with a control group of spherical equivalent less than -0.5 D. Genotyping of polymorphisms 1379 G/A (rs2288255) and 3171 C/G (rs-12507099), corresponding with 405 Gly/Ser and 1002 Thr/Ser variation in the BMP2K gene were determined by PCR-restriction fragment length polymorphism and associative study performed by comparing high myopic subjects and healthy controls. The frequency of A allele in the BMP2K gene 1379 G/A polymorphism showed a significant difference between cases and controls (P<0.001, OR = 2.99, 95% CI = 1.62-5.54) and subjects with either AA or AG genotype show higher risk than GG genotype (P<0.001, OR = 3.07, 95% CI = 1.59-5.92), while 3171 C/G polymorphism was not significant from this survey. These data suggest that BMP2K gene 1379 G/A variant is strongly correlated with high myopia and may contribute to a genetic risk factor for high degrees of myopic pathogenesis. J. Clin. Lab. Anal. 23:362-367, 2009. (C) 2009 Wiley-Liss, Inc.
    Relation: JOURNAL OF CLINICAL LABORATORY ANALYSIS 23 (6): 362-367
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

    Files in This Item:

    File Description SizeFormat
    0KbUnknown372View/Open
    101.doc44KbMicrosoft Word275View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback