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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8528


    Title: Type I IFN induced IL1-Ra expression in hepatocytes is mediated by activating STAT6 through the formation of STAT2 : STAT6 heterodimer
    Authors: Wan, L (Wan, Lei);Lin, CW (Lin, Cheng-Wen);Lin, YJ (Lin, Ying-Ju);Sheu, JJC (Sheu, Jim J. C.);Chen, BH (Chen, Bing-Hung);Liao, CC (Liao, Chiu-Chu);Tsai, Y (Tsai, Yuhsin);Lin, WY (Lin, Wei-Yong);Lai, CH (Lai, Chih-Ho);Tsai, FJ (Tsai, Fuu Jen)
    Contributors: Department of Bioinformatics
    Keywords: type I interferon;STAT6;STAT2;IL-1Ra;INTERLEUKIN-1 RECEPTOR ANTAGONIST;CHRONIC HEPATITIS-C;BLOOD MONONUCLEAR-CELLS;INTERFERON-ALPHA;SIGNAL-TRANSDUCTION;GENE-EXPRESSION;ANTIVIRAL STATE;TH1/TH2 BALANCE;TARGET GENES;PATHWAY
    Date: 2008-06
    Issue Date: 2010-03-26 10:56:39 (UTC+8)
    Publisher: Asia University
    Abstract: The biological activities of type I interferons (IFNs) are mediated by their binding to a heterodimer receptor complex (IFNAR1 and IFNAR2), resulting in the activation of the JAK (JAK1 and TYK2)-STAT (1, 2, 3, 5 isotypes) signalling pathway. Although several studies have indicated that IFN-alpha and IFN-beta can activate complexes containing STAT6, the biological role of this activation is still unknown. We found that exposure of hepatoma cells (HuH7 and Hep3B) to IFN-alpha or IFN-beta led to the activation of STAT6. Activated STAT6 in turn induced the formation of STAT2: STAT6 complexes, which led to the secretion of IL-1Ra. The activation of STAT6 by type I IFN in hepatocytes was mediated by JAK1 and Tyk2. In addition, IFN-alpha or IFN-beta significantly enhanced the stimulatory effect of IL-1 beta on production of IL-1Ra. The present study suggests a novel function of IFN-alpha and IFN-beta signalling in human hepatocytes. Our results provide evidence for the mechanism how IFN-alpha and IFN-beta modulate inflammatory responses through activation of STAT6 and production of secreted IL-1Ra.
    Relation: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 12 (3): 876-888
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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