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| Title: | X-ray repair cross-complementing group 4 (XRCC4) promoter-1394*T-related genotype, but not XRCC4 codon 247/intron 3 or xeroderma pigmentosum group D codon 312, 751/promoter-114, polymorphisms are correlated with higher susceptibility to myoma |
| Authors: | Hsieh, YY (Hsieh, Yao-Yuan);Chang, CC (Chang, Chi-Chen);Bau, DT (Bau, Da-Tian);Yeh, LS (Yeh, Lian-Shen);Tsai, FJ (Tsai, Fuu-Jen);Tsai, CH (Tsai, Chang-Hai) |
| Contributors: | Department of Bioinformatics |
| Keywords: | DNA repair;leiomyoma;polymorphism;xeroderma pigmentosum;XRCC4;BREAST-CANCER RISK;LUNG-CANCER;XPD POLYMORPHISMS;GENE XPD;COLORECTAL-CANCER;PANCREATIC-CANCER;GROUP-A;DNA;POPULATION;CHEMOTHERAPY |
| Date: | 2008-10 |
| Issue Date: | 2010-03-26 10:56:43 (UTC+8) |
| Publisher: | Asia University |
| Abstract: | Objective: To investigate whether the DNA repair genes, X-ray repair cross-complementing group 4 (XRCC4) and xeroderma pigmentosum group D (XPD), could be useful markers for predicting leiomyoma susceptibility. Design: Prospective study. Setting: Departments of gynecology and genetics in medical center. Patient(s): Women were divided into leiomyoma (n = 120) and nonleiomyoma groups (n = 112). Intervention(s): XRCC4 (codon 247, promoter-1394, intron 3) and XPD (codon 312, codon 75 1, promoter - 114) polymorphisms were genotyped by polymerase chain reaction with restriction enzyme digestions. Main Outcome Measure(s): Genotypes and allelic frequencies in both groups were compared. Result(s): XRCC4 promoter - 1394*T-related genotype/alleles were associated with higher susceptibility of leiomyoma. Proportions of XRCC4 promoter -1394*T homozygote/heterozygote/G homozygote and T/G alleles were [1] 91.7%/6.7%/1.7% and 95%/5% and [2] 79.4%/17.9%/2.7% and 88.4%/11.6%, respectively. Five other single nucleotide polymorphisms were not correlated with leiomyoma susceptibilities. Proportions of XRCC4 codon 247*CC/CA/AA and XRCC4 intron 3*Pi/ID/DD were [1] 95%/50%/0% and 72.5%/23.3%/4.2% and [2] 97.3%/2.7%/0 and 70.5%/24.1%/5.4%. Proportions of XPD codon 312*GG/GA/AA, XPD codon 75 1 *TT/TG/ GG, and XPD promoter -114*GG/GC/CC were [1] 65%/22.5%/12.5%, 92.5%/6.7%/0.8%, and 22.5%/46.7%/ 30.8%; and [2] 64.3%/22.3%/13.4%,92%/7.1%/0.9%, and 23.2%/46.4%/30.4%. Conclusion(s): XRCC4 promoter -1394*T-related genotype/alleles are associated with higher susceptibility of leiomyoma, whereas XRCC4 codon 247, XRCC4 intron 3, XPD codon 312, XPD codon 75 1, and XPD promoter - 114 polymorphisms are not correlated with its development. |
| Relation: | FERTILITY AND STERILITY, 90: 1417-1423 Suppl. |
| Appears in Collections: | [生物資訊與醫學工程學系 ] 期刊論文
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| 275.docx | | 0Kb | Unknown | 572 | View/Open | | 310904400-8537.doc | | 44Kb | Microsoft Word | 403 | View/Open |
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