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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8645

    Title: Briaexcavatins V-Z, discovery of new briaranes from a cultured octocoral briareum excavatum
    Authors: Sung, Ping-Jyun;Lin, Mei-Ru;Chiang, Michael Y.;Hwang, Tsong-Long
    Contributors: Department of Bioinformatics
    Keywords: Oxygen;X ray diffraction;Epoxy group;Human neutrophil;Human neutrophil elastase;Inhibitory effect;NMR chemical shifts;Single crystal x-ray diffraction;Spectroscopic method;Superoxide anions
    Date: 2009
    Issue Date: 2010-04-07 21:21:14 (UTC+8)
    Publisher: Asia University
    Abstract: Five new briarane derivatives, briaexcavatins V-Z(1-5), have been isolated from a cultured octocoral Briareum excavatum. The structures of compounds 1-5 were established by spectroscopic methods. Single-crystal X-ray diffraction data for 2 confirmed the structure. Briarane 4 possesses an unprecedented 8, 9-epoxy moiety. The relationships between <sup>13</sup>C NMR chemical shifts and the conformations of briaranes possessing an 11, 12-epoxy group are described. Briaranes 1, 3, and 4 have displayed weak inhibitory effects on superoxide anion generation by human neutrophils. Briarane 1 was found to show mild inhibitory effects on human neutrophil elastase release and 5 exhibited mild activity to enhance human neutrophil elastase release. © 2009 The Chemical Society of Japan.
    Relation: Bulletin of the Chemical Society of Japan 82(8):987-996
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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