ASIA unversity:Item 310904400/86900
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/86900


    题名: Distinct Subpopulations of Head and Neck Cancer Cells with Differential Intracellular ROS Exhibiting Diverse Chemoresistance, Stemness and Proliferative Activity
    作者: Ching-Wen, C;Chang, Ching-Wen;Ch, Yu-Syuan;Chen, Yu-Syuan;Shiu-Huey, C;Chou, Shiu-Huey;Han, Chia-Li;Han, Chia-Li;Chen, Yu-Ju;Chen, Yu-Ju;Cheng-Chieh;Yang, Cheng-Chieh;黃志揚;Huang, Chih-yang;Lo, Jeng-Fan;Lo, Jeng-Fan;*
    贡献者: 生物科技學系
    日期: 2014
    上传时间: 2014-11-07 14:47:46 (UTC+8)
    摘要: Head and neck squamous cell carcinoma (HNSCC) is driven by cancer-initiating cells (CIC), but their maintenance mechanisms are obscure. For hematopoietic stem cells, low levels of intracellular reactive oxygen species (ROS(Low)) is known to help sustain stemness properties. In this report, we evaluated the hypothesis that ROS(Low) character conferred CIC properties in HNSCC. Sphere cultures define CIC in HNSCC cell populations (HN-CIC). We found that ROS(Low) cells in HN-CIC defined in this manner were more numerous than in parental HNSCC cells. Further, ROS(Low) cells frequently coexpressed CIC surface markers such as memGrp78 and Glut3. Exploiting flow cytometry to sort cells on the basis of their ROS level, we found that isolated ROS(Low) cells displayed relatively more CIC properties, including quiescence, chemoresistance, in vitro malignant properties, and tumorigenicity. Pharmacological depletion of ROS modulators in cisplatin-treated HN-CIC reduced CIC properties, enhancing cell differentiation and enhancing cisplatin-induced cell death. Overall, our work defined cell subpopulations in HNSCC on the basis of differential intracellular ROS levels, which associated with stemness and chemoresistance properties. On the basis of our findings, we suggest that strategies to promote intracellular ROS levels may heighten the efficacy of conventional chemotherapy used for HNSCC treatment.
    ©2014 American Association for Cancer Research.
    關聯: CANCER RESEARCH;74(21):6291-305.
    显示于类别:[生物科技學系] 期刊論文

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