ASIA unversity:Item 310904400/87118
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    题名: High Level of Plasma Matrix Metalloproteinase-11 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
    作者: Hs, Chung-Han;Hsin, Chung-Han;Chen, Mu-Kuan;Chen, Mu-Kuan;湯智昕;Chih-Hsin, Tang;Li, Huang-Pin;Lin, Huang-Pin;Ch, Ming-Yung;Chou, Ming-Yung;Li, Chiao Wen;Lin, Chiao Wen;Yang, Shun-Fa;Yang, Shun-Fa
    贡献者: 生物科技學系
    日期: 2014-11
    上传时间: 2014-12-16 17:01:35 (UTC+8)
    摘要: Background

    Matrix metalloproteinase-11 (MMP-11) is reported to be overexpressed in several cancers and may contribute to tumorigenesis. The current study investigated the association between the clinicopathological characteristics and plasma level of MMP-11 in oral squamous cell carcinoma (OSCC) patients.

    Methodology and Principal Findings

    The plasma MMP-11 concentration was determined by ELISA on 330 male OSCC patients. In addition, the metastatic effects of the MMP-11 knockdown on the oral cancer cells were investigated by cell migration assay. Our results showed that the plasma MMP-11 levels were significantly higher in patients with advanced T status (p = 0.001), lymph node metastasis (p = 0.006) and higher TNM stages (p<0.001). Moreover, treatment with the MMP-11 shRNA exerted an inhibitory effect on migration in SCC9 oral cancer cells.

    Conclusion

    Our study showed that plasma level of MMP-11 may be useful for assessment of the disease progression, especially lymph node metastasis, in patients with OSCC.
    關聯: PLoS One
    显示于类别:[生物科技學系] 期刊論文

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