English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90069/105176 (86%)
Visitors : 6528717      Online Users : 568
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8776


    Title: Drug design for the influenza A virus subtype H1N1
    Authors: Chen, Chien-Yu;Bau, Da-Tian;Tsai, Ming-Hsui;Hsu, Yuan-Man;Ho, Tin-Yun;Huang, Hung-Jin;Chang, Yea-Huey;Tsai, Fuu-Jen;Tsai, Chang-Hai;Chen, Calvin Yu-Chian
    Contributors: Department of Bioinformatics
    Keywords: Biomedical engineering;Computer crime;Docking;Hydrogen bonds;Molecular graphics;Viruses;Candidate drugs;Drug Design;Hydrogen bond acceptors;Hydrogen bond donors;Influenza A virus;Me-xico;Neuraminidase;Pharmacophores;Potent inhibitor;QSAR model;Scientific applications
    Date: 2009
    Issue Date: 2010-04-08 20:05:59 (UTC+8)
    Publisher: Asia University
    Abstract: In March and April 2009, an outbreak of H1N1 influenza in Mexico led to hundreds of confirmed cases and a number of deaths. The worldwide spread of H1N1 had attracted everyone's attention and arisen an overwhelm fear. Up to now, there is still an urgent need in the solution for ending this fight. In this study, a QSAR model of neuraminidase (NA) type 1 (N1) provides an access. The pharmacophore map of N1 contained two hydrogen bond acceptor features, one hydrogen bond donor features, and one positive ionizable feature .NCI database was screened by this map to find potent inhibitors of N1. Then, those inhibitors were docked into hemagglutinin type 1 to find out the candidate drugs. The candidate drugs selected via computer-aided drug designing program may be very useful in this worldwide disease, and further investigations in its clinical and scientific application are urgently needed. ©2009 IEEE.
    Relation: Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
    Appears in Collections:[生物資訊與醫學工程學系 ] 會議論文

    Files in This Item:

    File Description SizeFormat
    0KbUnknown309View/Open
    310904400-8776.doc45KbMicrosoft Word463View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback