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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8779


    Title: A platform for identifying microRNA targeting genes
    Authors: Weng, Chia-Wei;Chiang, ChangChih;Ng, Ka-Lok;Huang, Chien-Hung
    Contributors: Department of Bioinformatics
    Keywords: Binding energy;Free energy;Genes;Tumors;MicroRNA;MicroRNA expression profile;mRNA expression profile;Oncogene;Tumor suppressor gene
    Date: 2009
    Issue Date: 2010-04-08 20:06:01 (UTC+8)
    Publisher: Asia University
    Abstract: We investigate the possibility that microRNA could act as an oncogene or tumor suppressor gene. Experimentally verified microRNA targeted genes information are integrated with microRNA and mRNA expression data to study this hypothesis, in which the Pearson correlation coefficient is used to quantify these relations. Cancer related microRNA and genes information are retrieved by literature search. Two microRNA targets prediction tools, miRanda and RNAHybrid, are used to obtained the binding minimum free energy and 3'UTR binding position for the target. A web based interface is set up for data display, which can be accessed at http://ppi.bioinfo.asia.edu.tw/mirna-target. © 2009 IEEE.
    Relation: Proceedings of the 2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009 :386-387
    Appears in Collections:[生物資訊與醫學工程學系 ] 會議論文

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