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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8795

    Title: Physiochemical constraints in influenza A hemagglutinin
    Authors: Chang, Pei-Chun;Shieh, Jiunn-I;Wang, Jing-Doo;Lee, Kuei-Jen;Li, Chung-Hung;Liu, Hsiang-Chuan
    Contributors: Department of Bioinformatics
    Keywords: Biological materials;Integral equations;Microorganisms;Nucleic acids;RNA;Viruses;Choquet integrals;Cross species;Fuzzy measures;Hurst exponents;Influenza A viruses;Inter-dependences;Phylogenetic analyses;Physico-chemical properties;Rna viruses;Single residues;Variations of
    Date: 2008
    Issue Date: 2010-04-08 20:06:11 (UTC+8)
    Publisher: Asia University
    Abstract: Influenza A viruses are negative-strand RNA viruses. The gene of hemagglutinin (HA) protein in the virus genome is the major molecule that determines the range of hosts. Mutation of HA gene may bring infection cross species. In this paper, we studied physicochemical constraints during the variations of HA gene. Fuzzy measure and Choquet integral were used to estimate the combining effect of different physicochemical properties for single residue in HA protein that related to infective events. With this method, an HA sequence was quantified residue by residue and produced a series of values. Finally, the Hurst exponent was adopted to infer the constraints in the series. We found that the physicochemical constraints in HA sequences mainly falling into two classes of interdependence strength during gene variation, that was distinct from the diversity of clusters in the phylogenetic analysis. © 2008 IEEE.
    Relation: Proceedings - 4th International Conference on Natural Computation, ICNC 2008 5 :85-89
    Appears in Collections:[生物資訊與醫學工程學系 ] 會議論文

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