Osteogeneesis imperfecta (OI) is a congenital condition with very fragile bone and the patients are extremely prone to fractures. General classroom teachers in primary schools are often concern about their knowledge and ability to care for students with OI and subsequently, they tend to resist in teaching them. Thus, the attitude of teachers plays an important role in learning effectiveness of students with OI. The purpose of this study was to investigate the effect of demographic variables, special education training, and external support system on the attitude towards OI students in general classroom teachers in primary school. A self-report questionnaire was administrated to 138 general classroom teachers from 5 primary schools in Taichung. The results showed that supporting teaching strategy, those without special education training and without working experience with OI students have positive influence on the attitude towards OI students. However, higher the acceptance with professional special education assistance for the teachers, more negative attitude toward OI students. Therefore, in those general classroom teachers without special education background or working experience with OI students, supporting teaching strategy can increase the acceptance for them. Nevertheless, the psychological stress of perception of professional insufficiency on those teachers should be addressed.