English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90451/105768 (86%)
Visitors : 11134494      Online Users : 508
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    ASIA unversity > 資訊學院 > 資訊工程學系 > 期刊論文 >  Item 310904400/88241


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/88241


    Title: A Novel BLAST-Based Relative Distance;BBRD;Method Can Effectively Group Members of Protein Arginine Methyltransferases and Suggest their Evolutionary Relationship.
    Authors: Wang, Yi-Chun;Wang, Yi-Chun;王經篤;Wang, Jing-Doo;Che, Chin-Han;Chen, Chin-Han;Chen, Yi-Wen;Chen, Yi-Wen;Li, Chuan;Li, Chuan
    Contributors: 資訊工程學系
    Keywords: MOLECULAR PHYLOGENETICS AND EVOLUTION
    Date: 2015-03
    Issue Date: 2015-03-25 14:17:26 (UTC+8)
    Abstract: We developed a novel BLAST-Based Relative Distance (BBRD) method by Pearson's correlation coefficient to avoid the problems of tedious multiple sequence alignment and complicated outgroup selection. We showed its application on reconstructing reliable phylogeny for nucleotide and protein sequences as exemplified by the fmr-1 gene and dihydrolipoamide dehydrogenase, respectively. We then used BBRD to resolve 124 protein arginine methyltransferases (PRMTs) that are homologues of nine mammalian PRMTs. The tree placed the uncharacterized PRMT9 with PRMT7 in the same clade, outside of all the Type I PRMTs including PRMT1 and its vertebrate paralogue PRMT8, PRMT3, PRMT6, PRMT2 and PRMT4. The PRMT7/9 branch then connects with the type II PRMT5. Some non-vertebrates contain different PRMTs without high sequence homology with the mammalian PRMTs. For example, in the case of Drosophila arginine methyltransferase (DART) and Trypanosoma brucei methyltransferases (TbPRMTs) in the analyses, the BBRD program grouped them with specific clades and thus suggested their evolutionary relationships. The BBRD method thus provided a great tool to construct a reliable tree for members of protein families through evolution.
    Copyright © 2015 Elsevier Inc. All rights reserved.
    Relation: 王經篤;84:101-11.
    Appears in Collections:[資訊工程學系] 期刊論文

    Files in This Item:

    File SizeFormat
    index.html0KbHTML90View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback