English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90453/105671 (86%)
Visitors : 16006445      Online Users : 71
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/89819

    Title: Protective Effect of Q10 on Rat Hearts of Doxorubicin Induced CardiomyopathyEffect of K.pneumoniae Infection on Hearts of Diabetic BLAB/c Mice
    Authors: Liu, Zhao-Rong
    Contributors: 生物科技學系
    Keywords: Q10;doxorubicin;cardiomyopathy;diabetic;K.pneumoniae
    Date: 2015
    Issue Date: 2015-09-30 16:21:49 (UTC+8)
    Publisher: 亞洲大學
    Abstract: Doxorubicin is a widely chemotherapeutic drug for treat-ing cancer, but doxorubicin is dose dependent to damage heart cause cardiac toxicity. Q10 might effectively reduce cardiotoxicity caused by doxorubicin, to protect the function of the heart, often used in the medical nutritional supplements on cancer treatment. This study focuses on previously used Q10 whether can achieve the prevention of cardiovascular disease caused by doxorubicin treatment.
    4 weeks SD rats adapt lab for 4 weeks as animal model and randomly divided into control, doxorubicin, oral Q10 treatment by doxorubicin (Dox+Q10) and Q10 four groups, control group is oral water 10 ml/kg every day and IP physio-logical saline, doxorubicin groups is IP doxorubicin 2.5 mg/kg every three days and Q10 groups is oral Q10 10 mg/kg every day, all groups treat 3 weeks and then animal sacrifice, analysis heart weight by one way ANOVA statistics and western blot analysis TGF β1, CTGF, COL1A1, MMP-9 and MMP-2 in fibrosis pathway, Bak, Bax, cytochrome c, caspase-9 and caspase-3 in apoptosis and p-PI3K, p-Akt, p-Bad, Bcl-2 and Bcl-xL in survival by mitochondria dependent pathway, Fas-L, FADD and caspase-8 in cell death pathway. Found heart of doxorubicin damage caused decreased heart weight, cardiomyocytes arrangement disarray and numerous of collagen accumulation, enhanced fibrosis pathway and cell death pathway, inhibited survival protein to cause cardiomyocytes apoptosis. However, advance use Q10 then damaged by doxorubicin, Q10 can protect cardiomyocytes and reduce fibrosis pathway and cell death pathway protein expression, enhance sruvival protein expression and inhibit cardiomyocytes apoptosis. Therefore, Q10 can indeed found to prevent heart damage caused by doxorubicin achieve a protective effect.
    Appears in Collections:[生物科技學系] 博碩士論文

    Files in This Item:

    File Description SizeFormat

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback