ASIA unversity:Item 310904400/91984
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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/91984


    题名: Improvement of glycemic control in streptozotocin-induced diabetic rats by atlantic salmon skin gelatin hydrolysate as the dipeptidyl-peptidase IV inhibitor
    作者: 謝承紘;Hsieh, Cheng-Hong;王子源;Wang, Tzu-Yuan;洪娟娟;Hung, Chuan-Chuan;陳孟君;Chen, Meng-Chun;徐國強;Hsu, Kuo-Chiang
    贡献者: 圖書館
    日期: 2015-06
    上传时间: 2015-10-08 14:27:29 (UTC+8)
    摘要: In our previous study, Atlantic salmon skin gelatin hydrolysed with flavourzyme possessed 42.5% DPP-IV inhibitory activity at the concentration of 5 mg/mL. The oral administration of hydrolysate (FSGH) at single dose of 300 mg/d in streptozotocin (STZ)-induced diabetic rats for 5 weeks was evaluated for its antidiabetic effect. During the 5-week experiment, body weight was increased, food and water intake were reduced by FSGH in diabetic rats. The daily administration of FSGH for 5 weeks was effective to lower the blood glucose levels of diabetic rats during oral glucose tolerance test (OGTT). After 5-week treatment, plasma dipeptidyl peptidase (DPP)-IV activity was inhibited; plasma active glucagon-like peptide-1 (GLP-1), insulin and insulin-to-glucagon ratio were increased by FSGH in diabetic rats. The results indicate that FSGH has the function of inhibiting GLP-1 degradation by DPP-IV, resulting in the enhancement of insulin secretion and improvement of glycemic control in STZ-induced diabetic rats.
    關聯: Food & Function
    显示于类别:[醫學暨健康學院] 期刊論文


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