ASIA unversity:Item 310904400/9419
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90120/105278 (86%)
Visitors : 8949883      Online Users : 70
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item:

    Title: 利用綠色化學製備選擇性雌激素受體調節劑系列藥物技術開發
    Authors: 李傳珍
    Contributors: 健康學院
    Date: 2009
    Issue Date: 2010-05-07 11:38:06 (UTC+8)
    Abstract: 綠色化學的技術是以污染性低的清潔生產,使用對人類健康及環境危害較小
    選擇性雌激素受體調節劑(Selective Estrogen Receptor Modulators,SERMs)是
    組織和激素的內環境不同,表現出雌激素激動劑或雌激素拮抗劑 (Antiestrogens)
    Green Chemistry is diffusing throughout the chemical industry and includes use
    and development of new substances and processes. Green Chemistry intends to
    eliminate intrinsic hazard itself, rather than focusing on reducing risk by minimizing
    exposure. Much of the chemical industry is capital-intensive, based on economies of
    scale, and thus large companies are typically slow to convert to new technologies.
    Estrogen receptor and endogenous estrogens play important roles in the development
    and function of female reproductive system. Selective estrogen receptor modulators
    (SERMs) which fully antagonize the effects of estrogen on uterine and mammary
    tissues, while mimicking the effects of estrogen on the bone and cardiovascular
    system have been investigated as a possible alternative to estrogen replacement
    therapy. Raloxifene has been treating for prevention of breast cancer and prevention
    of osteoporosis.
    In this proposal will development green chemistry method applies in synthesis series
    of SERMs. Using microreactor technology that small-scale commercial applications,
    reducing waste, include safety, potential performance enhancement, and
    environmental impact. The experiments will designed to use mix level orthogonal
    array to find optimized operation factors. Several parameters will studied and
    optimized, such as time of reaction, reaction temperature, reactant flow, kinds of ionic
    liquid. The products of detection also will be determined with chromatography and
    spectroscopy. If the proposal execute successfully will be carry out active
    pharmaceutical industry promote to manufacture, increase efficiency and prevent
    Appears in Collections:[Department of Food Nutrition and Healthy Biotechnology] Ministry of Science and Technology Research Project

    Files in This Item:

    File Description SizeFormat
    98李傳珍1.pdf66KbAdobe PDF581View/Open
    98李傳珍2.pdf35KbAdobe PDF385View/Open

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback