The aim of this study is to explore the relationship among job demands (working hours、 workload and work geographical restrictions)、 job control (alternative work and job autonomy)、 doctoral supports and work consequences (job satisfaction and job burnout), as well as to examine the moderating effect of job control and doctoral supports on all the main effects. The study collected data from 207 respiratory therapists from academic medical centers, metropolitan hospitals, and local community hospitals in Taiwan. A total of 200 participants returned valid responses making the valid response rate 97%. The results revealed that workload had negative effect on job satisfaction. On the contrary, work geographical restrictions had positive effect on job satisfaction. Workload had positive effect on job burnout, otherwhise, work geographical restrictions increased the degree of professional efficacy. Furthermore, the more ease of replacement and job autonomy they had, the more job satisfaction they ownd. The more ease of replacement, the less emotional exhaustion as well. Job autonomy was negatively related to job burnout. Respiratory therapists who had doctoral supports, felt more job satisfaction and less job burnout. Finally, doctoral supports could buffer the negative relationships between job demands and job satisfaction, as well as the positive relationships between job demands and emotional exhaustion. Job autonomy also could buffer the positive relationships between work geographical restrictions and depersonalization.