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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/9587


    Title: 經皮藥劑導入超聲波換能器陣設計及其系統研發(II)
    Authors: 陳永欽
    Contributors: 資訊工程學系
    資訊學院
    Keywords: 鈸型換能器
    換能器陣列
    超聲波藥物導入法
    皮膚浸入式藥劑導入系統
    控制系統
    Cymbal Transducer,
    Transducer Array
    Sonophoresis
    Transdermal Drug Delivery System
    Control System
    Date: 2009
    Issue Date: 2010-05-12 14:02:54 (UTC+8)
    Abstract: 近年來,以超聲波技術加強皮膚浸透度之皮下藥劑導入系統(Transdermal
    Drug Delivery System, 簡稱為TDDS)研究,吸引了相關科技人員高度的重視。這
    種非侵入性之給藥系統,將藥劑塗敷於皮膚上並利用超聲波之能量,使皮膚最外
    面之角質層(Stratum Cornum)瞬間孔位增大,增加了浸透性,讓藥劑順利流入皮
    膚內部組織,而被吸收之,而達成醫療效果,此一新型之給藥技術可取代口服藥
    (如止痛劑、消炎藥等)經人體肝臟代謝所產生的副作用,並可免除並人注射藥劑
    之疼痛與不適(如胰島素等),更能促進藥劑之被吸收。
    本計畫將研製一種使用在人體皮下藥劑導入(傳遞)的超聲波鈸型超聲換能
    器。針對普通壓電換能器形變行程較短的缺點,提出一種具有鈸型(Cymbal)結構
    的複合壓電陶瓷換能器(簡稱為鈸型超聲換能器)的結構設計,通過將壓電陶瓷微
    小的徑向位移放大,轉換成軸向位移,擴大了電換能器形變行程,可以達到良好
    的藥劑導入效果。本計畫將利用三年來完成一可攜式鈸型換能器陣列藥劑導入系
    統。
    第一年(97/8~98/7)預計從事鈸型超聲波換能器研製,經由換能器設計理論及
    軟體模擬,探討鈸型超聲波換能器之物理參數值(結構、材料、形狀、面積大小
    等)與其元件特性(形變行程、振動頻率、操作功率、機電藕合效率等)之關係,並
    研究製程技術以設計一高效能之鈸型超聲波換能器,使成變張(flextensional)
    振動模式,振動頻率在20kHz 左右。換能器之阻抗匹配設計也是研究重點之一。
    第二年(98/8~99/7) 預計從事鈸型超聲波換能器陣列研製,經由換能器陣列
    設計理論及軟體模擬,探討鈸型超聲波換能器陣列之波束圖之參數值(方向性指
    數、主波瓣寬度)與其鈸型超聲波換能器元件特性及排列方式(此一陣列可由四顆
    (2x2)或九顆(3x3)鈸型超聲換能器組成)之關係,使成一寬頻帶超聲波換能器元件
    陣列,振動頻率在20kHz 左右。換能器陣列之量測系統研製也是研究重點之一。
    第三年(99/8~100/7) 預計從事鈸型超聲波換能器陣列之控制系統研製,包含
    其電子式波束成型電路、輸出功率調變、功率放大電路,通訊介面、顯示器介面
    之研製,並與去年研究成果組合成一可攜式鈸型換能器陣列藥劑導入系統。
    In this project, we tray to develop a portable Cymbal transducer array for
    transdermal drug delivery application.
    Recently, ultrasound enhanced transdermal drug delivery technology (sonophoresis)
    has received increasing attention among the research fields of the drug delivery
    systems. Some drug doses such as antibiotic could be a metabolic burden to the liver.
    Management of diabetes such as insulin sometimes requires painful repetitive
    injections of insulin up to three times each day. To avoid these metabolic burden to
    the liver and continuous injections, noninvasive transdermal drug delivery has been
    considered. The ultrasound enhanced transdermal drug delivery can make the drug
    such as insulin in vivo easy to traverse the stratum corneum and subsequently to the
    reach capillary vessels to be absorbed.
    This research presents the development of a cymbal-type transducer for
    Transdermal drug delivery applications. Because the piezoelectric transducers using
    conventional PZT ceramics cannot provide the desired deformation, the Cymbal
    transducer is developed to increase amplification of displacement by converting radial
    displacement into large longitudinal displacement and improve the performance of the
    transdermal drug delivery system(TDDS). A portable Cymbal transducer array for
    transdermal drug delivery will be developed in this project, and this research project is
    schedule for three years.
    In the First year (2008/8~2009/7), the design theorem of the Cymbal transducers
    will be studied. Physical factors (such as structure, cavity depths, cap thickness,
    materials, and dimension) that affects the properties (such as displacement, resonance
    frequency, driving power, electromechanical coupling efficiency) of the transducer
    device will be discussed by using the simulation software of finite element methods.
    After that a Cymbal transducer with resonance frequency of 20kHz is developed and
    fabricated. The impedance matching of the transducer is also a research issue in this
    year.
    In the second year (2009/8~2010/7), the design theorem of the transducers array
    will be studied. Array made up of Cymbal transducers with different combinations
    ( two by two or three by three ) that affects the array properties (such as directivity
    and width of main lobe) will be discussed by using the simulation software. After that
    a Cymbal transducer array with operation frequency of 20kHz is developed and
    fabricated. The development of automatic testing system for the transducer array is
    also an important research issue during the year.
    In the third year(2010/8~2011/7), A array control system consisting beamformeing
    module, output power modulation module, power amplifier module, signal
    manipulation module and interface of communication and display will be developed .
    Appears in Collections:[資訊工程學系] 科技部研究計畫

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