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    Title: 經皮藥劑導入超聲波換能器陣設計及其系統研發(II)
    Authors: 陳永欽
    Contributors: 資訊工程學系
    Keywords: 鈸型換能器
    Cymbal Transducer,
    Transducer Array
    Transdermal Drug Delivery System
    Control System
    Date: 2009
    Issue Date: 2010-05-12 14:02:54 (UTC+8)
    Abstract: 近年來,以超聲波技術加強皮膚浸透度之皮下藥劑導入系統(Transdermal
    Drug Delivery System, 簡稱為TDDS)研究,吸引了相關科技人員高度的重視。這
    面之角質層(Stratum Cornum)瞬間孔位增大,增加了浸透性,讓藥劑順利流入皮
    振動模式,振動頻率在20kHz 左右。換能器之阻抗匹配設計也是研究重點之一。
    第二年(98/8~99/7) 預計從事鈸型超聲波換能器陣列研製,經由換能器陣列
    陣列,振動頻率在20kHz 左右。換能器陣列之量測系統研製也是研究重點之一。
    第三年(99/8~100/7) 預計從事鈸型超聲波換能器陣列之控制系統研製,包含
    In this project, we tray to develop a portable Cymbal transducer array for
    transdermal drug delivery application.
    Recently, ultrasound enhanced transdermal drug delivery technology (sonophoresis)
    has received increasing attention among the research fields of the drug delivery
    systems. Some drug doses such as antibiotic could be a metabolic burden to the liver.
    Management of diabetes such as insulin sometimes requires painful repetitive
    injections of insulin up to three times each day. To avoid these metabolic burden to
    the liver and continuous injections, noninvasive transdermal drug delivery has been
    considered. The ultrasound enhanced transdermal drug delivery can make the drug
    such as insulin in vivo easy to traverse the stratum corneum and subsequently to the
    reach capillary vessels to be absorbed.
    This research presents the development of a cymbal-type transducer for
    Transdermal drug delivery applications. Because the piezoelectric transducers using
    conventional PZT ceramics cannot provide the desired deformation, the Cymbal
    transducer is developed to increase amplification of displacement by converting radial
    displacement into large longitudinal displacement and improve the performance of the
    transdermal drug delivery system(TDDS). A portable Cymbal transducer array for
    transdermal drug delivery will be developed in this project, and this research project is
    schedule for three years.
    In the First year (2008/8~2009/7), the design theorem of the Cymbal transducers
    will be studied. Physical factors (such as structure, cavity depths, cap thickness,
    materials, and dimension) that affects the properties (such as displacement, resonance
    frequency, driving power, electromechanical coupling efficiency) of the transducer
    device will be discussed by using the simulation software of finite element methods.
    After that a Cymbal transducer with resonance frequency of 20kHz is developed and
    fabricated. The impedance matching of the transducer is also a research issue in this
    In the second year (2009/8~2010/7), the design theorem of the transducers array
    will be studied. Array made up of Cymbal transducers with different combinations
    ( two by two or three by three ) that affects the array properties (such as directivity
    and width of main lobe) will be discussed by using the simulation software. After that
    a Cymbal transducer array with operation frequency of 20kHz is developed and
    fabricated. The development of automatic testing system for the transducer array is
    also an important research issue during the year.
    In the third year(2010/8~2011/7), A array control system consisting beamformeing
    module, output power modulation module, power amplifier module, signal
    manipulation module and interface of communication and display will be developed .
    Appears in Collections:[Department of Computer Science and Information Engineering] Ministry of Science and Technology Research Project

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