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    ASIA unversity > 資訊學院 > 光電與通訊學系 > 期刊論文 >  Item 310904400/96308


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/96308


    Title: Effects of paeonol on anti-neuroinflammatory responses in microglial cells
    Authors: Chingju Lin;Chingju Lin;Hsiao-Yun Li;Hsiao-Yun Lin,;Jia-Hong Che;Jia-Hong Chen;Wen-Pei Tsen;Wen-Pei Tseng;Pei-Ying Ko;Pei-Ying Ko;Yu-Shu Liu;Yu-Shu Liu;Wei-Lan Yeh;Wei-Lan Yeh;盧大宇;Dah-Yuu Lu*
    Contributors: 光電與通訊學系
    Date: 2015-04
    Issue Date: 2015-12-11 14:13:02 (UTC+8)
    Abstract: Increasing studies suggest that inflammatory processes in the central nervous system mediated by microglial activation plays an important role in numerous neurodegenerative diseases. Development of planning for microglial suppression is considered a key strategy in the search for neuroprotection. Paeonol is a major phenolic component of Moutan Cortex, widely used as a nutrient supplement in Chinese medicine. In this study, we investigated the effects of paeonol on microglial cells stimulated by inflammagens. Paeonol significantly inhibited the release of nitric oxide (NO) and the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Treatment with paeonol also reduced reactive oxygen species (ROS) production and inhibited an ATP-induced increased cell migratory activity. Furthermore, the inhibitory effects of neuroinflammation by paeonol were found to be regulated by phosphorylated adenosine monophosphate-activated protein kinase-α (AMPK-α) and glycogen synthase kinase 3 α/β (GSK 3α/β). Treatment with AMPK or GSK3 inhibitors reverse the inhibitory effect of neuroinflammation by paeonol in microglial cells. Furthermore, paeonol treatment also showed significant improvement in the rotarod performance and microglial activation in the mouse model as well. The present study is the first to report a novel inhibitory role of paeonol on neuroinflammation, and presents a new candidate agent for the development of therapies for inflammation-related neurodegenerative diseases.
    Relation: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    Appears in Collections:[光電與通訊學系] 期刊論文

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